Century Therapeutics and Outpace Bio Enter Research Collaboration in CAR Engineering

October 7, 2021

Collaboration enables Century to explore Outpace’s protein solutions for cell therapy to enhance functionality of iPSC platform

Initial program to focus on hematological malignancies with option to expand to additional candidates

PHILADELPHIA, Oct. 07, 2021 (GLOBE NEWSWIRE) -- Century Therapeutics (NASDAQ: IPSC), an innovative biotechnology company developing induced pluripotent stem cell (iPSC)-derived cell therapies in immuno-oncology, and Outpace Bio, a cutting-edge biotechnology company building a platform to create next-generation smart cell therapies today announced a research collaboration in CAR engineering.

The collaboration will bring together Century’s CAR and protein engineering expertise with Outpace’s protein design and synthetic biology capabilities to enhance CAR functionality by combining Outpace’s optimized CAR spacer technology with Century’s VHH domain binders.

“As an emerging leader in iPSC-based cell therapy, investing in cutting edge cell engineering technologies is central to our approach to develop transformational next generation allogeneic cell therapies,” said Lalo Flores, Chief Executive Officer, Century Therapeutics. “The collaboration with Outpace will further enhance our protein engineering capabilities and potentially accelerate development of our proprietary next generation CARs.”

“We are excited to work together with Century to create highly optimized CARs for their exciting iPSC-based cell therapies,” said Marc Lajoie, CEO, and co-founder of Outpace. “This collaboration provides an ideal opportunity to accelerate the impact of Outpace’s spacer technology, which is part of our broader platform to enhance T cell therapies, and in turn Outpace’s protein design capabilities offer improved functionality and optionality to Century’s iPSC platform and product candidates.”

Under the terms of the agreement, Outpace will bring forward its spacer library and generate an in vitro data package of binder-spacer combinations for Century approval and selection of a candidate. Century will assess functionality in indication-relevant tumor models in vitro and in vivo.

About Century Therapeutics

Century Therapeutics (NASDAQ: IPSC) is harnessing the power of adult stem cells to develop curative cell therapy products for cancer that we believe will allow us to overcome the limitations of first-generation cell therapies. Our genetically engineered, iPSC-derived iNK and iT cell product candidates are designed to specifically target hematologic and solid tumor cancers. We are leveraging our expertise in cellular reprogramming, genetic engineering, and manufacturing to develop therapies with the potential to overcome many of the challenges inherent to cell therapy and provide a significant advantage over existing cell therapy technologies. We believe our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care. For more information on Century Therapeutics please visit www.centurytx.com.

About Outpace Bio

Outpace Bio is creating next generation smart cell therapies using groundbreaking protein design and synthetic biology to reprogram how cells function and make decisions. Outpace collaborates with industry leaders to dramatically improve the safety and efficacy of cell and gene therapies, combining Outpace’s mechanism-driven solutions with partners’ biological insights, development capabilities, and clinical expertise to accelerate the discovery of curative therapies. With roots from David Baker’s Lab at the University of Washington and Lyell Immunopharma, Outpace’s versatile platform combines the design of improved biological functions with powerful cellular control modalities, harnessing the full complexity of cellular biology to tackle incurable disease. For more information visit outpacebio.com and follow on Twitter and Instagram @OutpaceBio.

Century Therapeutics Forward-Looking Statement

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Century Therapeutics Investor Contact:
Elizabeth Krutoholow

Century Therapeutics Media Contact:

Outspace Bio Media Contact:
Allison Braley, Playground Global for Outpace Bio